Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants). However, HME requires considerable amounts of material even at small-scale (>2 g batch size). In this study, we introduced vacuum compression molding (VCM) as a predictive screening tool of protein stability for potential HME processing. The focus was to identify appropriate polymeric matrices prior to extrusion and evaluation of protein stability after thermal stress using only a few milligrams of protein. The protein stability of lysozyme, BSA, and human insulin embedded in PEG 20,000, PLGA, or EVA by VCM was investigated by DSC, FT-IR, and SEC. The results from the protein-loaded discs provided important insights into the solid-state stabilizing mechanisms of protein candidates. We demonstrated the successful application of VCM for a set of proteins and polymers, showing, in particular, a high potential for EVA as a polymeric matrix for solid-state stabilization of proteins and the production of extended-release dosage forms. Stable protein-polymer mixtures with sufficient protein stability after VCM could be then introduced to a combination of thermal and shear stress by HME and further investigated with regard to their process-related protein stability.

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

AAPS PharmSciTech

Pharmaceutics, Free Full-Text

Pharmacology Research & Perspectives - Wiley Online Library

Pharmaceutics, Free Full-Text

Pksolver 2.0 Free Download - Colaboratory

Pharmaceutics, Free Full-Text

RePub, Erasmus University Repository: Paediatric formulations

Pharmaceutics, Free Full-Text

Detachment Film Get File - Colaboratory

Pharmaceutics, Free Full-Text

Understanding Pharma: The Professional's Guide to How

Pharmaceutics, Free Full-Text

High reprint orders in medical journals and pharmaceutical

Pharmaceutics, Free Full-Text

Introduction to Pharmaceutical chemistry

Pharmaceutics, Free Full-Text

Exploring Trends and Opportunities in the Pharma Secondary

Pharmaceutics, Free Full-Text

Pharmaceutical Development and Technology: Vol 28, No 10 (Current

Pharmaceutics, Free Full-Text

Cpc Keygen Get File - Colaboratory

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmaceutics, Free Full-Text

Pharmacy PowerPoint Template